2024
Feng T, Du H, Yang C, Wang Y, Hu F. Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice. Acta Neuropathologica. 2024 March 25. doi: 10.1007/s00401-024-02702-4
Yang C, Liu Y, Hu F. IkB kinase thwarts aggregation: Phosphorylating TDP-43 for degredation. Journal of Cell Biology. 2024 January 22. doi: https://doi.org/10.1083/jcb.202311176
2023
Lacrampe A, Hu F. Unveiling TMEM106B: SARS-CoV-2’s secret entrance to the cell. Cell. 2023 Aug 3;186(16):3329-3331. doi: 10.1016/j.cell.2023.07.005.
Feng T, Minevich G, Liu P, Qin HX, Wozniak G, Pham J, Pham K, Korgaonkar A, Kurnellas M, Defranoux NA, Long H, Mitra A, Hu F. AAV1/9-mediated expression of humanprogranulin corrects behavioral deficits and brain pathology in Tmem106b-/-Grn-/- mice. iScience. 2023 July 21. doi: 10.1016/j.isci.2023.107247
Pang W, Hu F C9ORF72 suppresses JAK-STAT mediated inflammation. iScience. Volume 26, Issue 5, 19 May 2023, 106579
Zhang T, Pang W, Feng T, Guo J, Wu K, Nunez Santos M, Arthanarisami A, Nana AL, Nguyen Q, Kim PJ, Jankowsky JL, Seeley WW, Hu F. TMEM106B regulates microglial proliferation and survival in response to demyelination Sci Adv. 2023 May 5;9(18):eadd2676.
Zhang T, Feng T, Wu K, Guo J, Nana AL, Yang G, Seeley WW, Hu F. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination. Acta Neuropathologica. 2023 Apr 30. doi: 10.1007/s00401-023-02578-w
Du H, Yang C, Nana AL, Seeley WW, Smolka M, Hu F Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation. bioRxiv. 2023 Apr 6:2023.04.06.535844. doi: 10.1101/2023.04.06.535844
2022
Nunez Santos M, Paushter DH, Zhang T, Wu X, Feng T, Lou J, Du H, Becker SM, Fragoza R, Yu H, Hu F. Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis. Journal of Biological Chemistry. 2022 Aug 4; 298(9):102348
Feng T, Luan L, Katz I, Ullah M, Van Deerlin V, Trojanowski J, Lee E, Hu F. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta Neuropathological Communications. 2022 Mar 14; 10:33
Zhang T, Du H, Nunez-Santos M, Wu X, Pagan M, Trigiani L, Nishimura N, Reinheckel T, Hu F. Differential regulation of progranulin derived granulin peptides. Molecular Neurodegeneration. 2022 Feb 04; 17:15
Du H, Zhou X, Feng T, Hu F. Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin. Brain Communications. 2022 Jan 04. doi: 10.1093/braincomms/fcab310
2021
Du H, Wong MY, Zhang T, Nunez Santos M, Hsu C, Zhang J, Yu H, Luo W, Hu F. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life Science Alliance. 2021 Jun 08. doi: 10.26508/lsa.202000874
Feng T, Lacrampe A, Hu F. Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders. Acta Neuropathologica. 2021 Jan 01. doi: 10.1007/s00401-020-02246-3
2020
Pang W, Hu F. Cellular and physiological functions of C9ORF72 and implications for ALS/FTD. Journal of Neurochemistry. 2020 Dec 01. doi: 10.1111/jnc.15255
Feng T, Mai S, Roscoe JM, Sheng RR, Ullah M, Zhang J, Katz II, Yu H, Xiong W, Hu F. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020 Aug 10:e50219. doi: 10.15252/embr.202050219.
Feng T, Sheng RR, Solé-Domènech S, Ullah M, Zhou X, Mendoza CS, Martinez Enriquez LC, Katz II, Paushter DH, Sullivan PM, Wu X, Maxfield FR, Hu F. A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. Brain, awaa154, https://doi.org/10.1093/brain/awaa154
2019
Zhou X, Paushter D, Pagan M, Kim D, Lieberman RL, Overkleeft HS, Sun Y, Smolka MB, Hu F. Progranulin deficiency results in reduced glucocerebrosidase activity. PloS One 2019 Jul 10;14(7):e0212382. doi: 10.1371/journal.pone.0212382. eCollection 2019.
Lan Y, Sullivan PM, Hu F. SMCR8 negatively regulates Akt and mTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis. Autophagy 2019 Jan 29:1-15. doi: 10.1080/15548627.2019.1569914
2018
Paushter D, Huan D, Feng T, Hu F. The lysosomal function of progranulin, a guardian against neurodegeneration. Acta Neuropathol. 2018 May 9. doi: 10.1007/s00401-018-1861-8.
Zhou X, Paushter D, Sullivan PM, Hu F#. The Interaction between progranulin with sortilin and the lysosome. Methods in Molecular Biology 2018;1806:269-288. Andrew Bateman et al. (Eds): Progranulin, 978-1-4939-8557-9, 329208_1_En, (18) doi: 10.1007/978-1-4939-8559-3_18.
2017
Zhou X, Paushter D, Feng T, Sun L, Reinheckel T, Hu F. Lysosomal processing of progranulin. Molecular Neurodegeneration. 2017 Aug 23;12:62
Zhou X, Paushter DH, Feng T, Pardon CM, Mendoza CS, Hu F. Regulation of cathepsin D activity by the FTLD protein progranulin. Acta Neuropathologica Communications. 2017 Jul;134(1):151-153
Zhou X, Sullivan P, Sun L, Hu F The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C. Journal of Neurochemistry 2017 June 22.
Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, & Hu F. Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations. Nature Communications 2017 May 25.
Zhou X, Sun L, Brady OA, Murphy KA, Hu F. Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency. Acta Neuropathologica Communications. 2017 Jan 26;5(9).
2016
Sullivan PM, Zhou X, Robins AM, Paushter DH, Kim D, Smolka MB, Hu F. The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. Acta Neuropathologica Communications. 2016 May 18:4(51).
2015
Zhou X, Sun L, Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F. Prosaposin facilitates sortilin independent lysosomal targeting of progranulin. J Cell Biol. 2015 Sep 14;210(6):991-1002.
Hsu F, Hu F, Mao Y. Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. J Cell Biol. 2015 Apr 13;209(1):97-110.
2014
Brady OA, Zhou X, Hu F. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration (FTLD) risk factor,TMEM106B, by Signal Peptide Peptidase-like 2a (SPPL2a). J Biol Chem. 2014 Jul 11;289(28):19670-19680
2013
Tian C, Shi H, Xiong S, Hu F, Xiong WC and Liu J. The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans. Development. 2013 Oct;140(19):4070-80.
Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. Acta Neuropathol Commun. 2013 Jul 11;1(1):36
Brady OA, Zheng , and Hu F. The Frontotemporal Lobe degeneration risk factor, TMEM106B, regulates lysosomal morphology and function. Hum Mol Genet. 2013 Feb 15;22(4):685-95.
2011
Zheng, Y, Brady, OA, Meng, PS, Mao Y and Hu F. C-terminus of Progranulin interacts with the beta-propeller region of Sortilin to regulate Progranulin trafficking. PLoS One 2011; 6(6): e21023.
Brady OA, Meng PS, Zheng Y, Mao Y and Hu F. Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1. Journal of Neurochemistry. 2011; 116(2): 248-59.
2010
Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A and Strittmatter SM.
Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin. 2010 Nov 18; 68(4): 654-67.
Manford A, Xia T, Saxena AK, Stefan C, Hu F, Emr SD, Mao Y. Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function. EMBO J. 2010 May 5; 29(9):1489-98.
2009
Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME, De Camilli P. A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J. 2009 July 8; 28(13): 1831–1842.
2008
Hu F and Strittmatter SM. The N-Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism. J Neurosci. 2008 Jan 30;28(5):1262-9.
2007
Laurén J, Hu F, Chin J, Liao J, Airaksinen MS and Strittmatter SM. Complex ligand-receptor interactions of myelin inhibitors of axon growth with Nogo-66 receptor family members. J Biol Chem. 2007 Feb 23;282(8):5715-25.
2006
Miao RQ, Gao Y, Harrison KD, Prendergast J, Acevedo LM, Yu J, Hu F, Strittmatter SM and Sessa WC. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10997-1002.
2005
Hu F, Liu B, Budel S, Chin J, Liao J, Fournier A and Strittmatter SM. Nogo-A interacts with the Nogo-66 receptor through multiple sites to create an isoform-selective subnanomolar agonist. J Neurosci. 2005 Jun 1;25(22):5298-304.
2004
Hu F and Strittmatter SM. Regulating axon growth within the postnatal central nervous system. Semin Perinatol. 2004 Dec;28(6):371-8.
2002
Hu F and Elledge SJ. Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle. 2002 Sep-Oct;1(5):351-5.
2001
Hu F, Y. Wang, D. Liu, Y.Li, J. Qin and Elledge SJ. Regulation of Bfa1 by Cdc5 and cell cycle checkpoints. Cell 2001 Nov 30;107:655-665.
Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr A, and Elledge SJ. Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat. Cell. Biol. 2001 Nov 1;3:958-965
Hu F, Alcasabas AA and Elledge SJ. Asf1 links Rad53 to control of chromatin assembly. Genes Dev. 2001 May 1;15(9):1061-6.
2000
Wang Y, Hu F and Elledge SJ. The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit. Curr Biol. 2000 Nov 2;10(21):1379-82.
1999
Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M and Elledge SJ. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science 1999 Nov 5;286(5442):1166-71.