The Hu Lab
The Hu lab is interested in studying molecular and cellular mechanisms involved in neuro-degeneration.
Frontotemporal Lobar Degeneration with ubiquitin and TDP-43 positive inclusions (FTLD-U) is a very common early onset dementia disease often associated with Amyotrophic Lateral Sclerosis (ALS). Mutations in Progranulin (PGRN), resulting in PGRN haplo-insufficiency, are one of the main causes of FTLD-TDP. A transmembrane protein of unknown function, TMEM106B, is a risk factor for FTLD-TDP with PGRN mutations. More recently, mutations in C9orf72, a gene of unknown function, were found to the main cause of mixed ALS/FTLD phenotypes. We are trying to understand the cellular functions of PGRN, TMEM106B and C9orf72 as well as other genes implicated in FTLD/ALS. We hope our studies will not only shed light on the molecular and cellular mechanisms of FTLD but also on the regulation of normal cellular functions by these FTLD proteins, such as regulation of autophagy-lysosome functions by PGRN, TMEM106B and C9orf72.
|Postdoctoral positions are currently available. We are seeking candidates who have a strong background in biochemistry, molecular biology, cell biology, or mouse genetics with interests in neurodegeneration.
- August 2017: Our paper on lysosomal progranulin processing is published and highlighted in ALZ forum!
- July 2017: Welcome new postdoc Huan Du to the lab!
- July 2017: Pete passed his B-exam! Congratulations, Dr. Sullivan!
- June 2017: Our paper on progranulin-prosaposin binding site is published!
- May 2017: Welcome new graduate student, Mariela N. Santos, from the BMCB field!
- May 2017: Our paper titled “Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations” is published in Nature Communications! Good job, Xiaolai!
- May 2017: Our manuscript on progranulin and cathepsin D interaction is published in Acta Neuropathologica!
- March 2017: Congratulations to Pete Sullivan on winning the Harry and Samuel Mann Outstanding Graduate Student Award!
- January 2017: Welcome undergraduate Elizabeth Milstein to the lab!
- January 2017: Our manuscript on the interaction between PRGN and TMEM106B is accepted for publication!
- December 2016: Welcome postdoc Tuancheng Feng and visiting scientist Yungang Lan to the lab!
- August 2016: Welcome undergraduates Stephanie Becker, Sam Huang, Helen Kwon, Christina Mendoza and Alice Tan to the lab!
- July 27th 2016: Dan Paushter passed his A-exam. Congratulations!
- May 2016: Our manuscript on ALS/FTLD associated protein C9orf72 is accepted for publication!
- September 2015: Our paper titled “Prosaposin facilitates sortilin independent lysosomal targeting of progranulin” is published in the Journal of Cell Biology and highlighted. Good job, Xiaolai and Lirong!
- May 2015: Welcome to DVM/Ph.D. Student, Daniel Paushter!
- September 2014: Xiaolai is awarded the Weill Institute Postdoctoral Fellowship. Congratulations!
- August 28, 2014: Peter Sullivan passed his A-exam. Congratulations!
- May 2014: Our paper on TMEM106B cleavage by SPPL2a is accepted for publication.
- Dec. 2013: Congratulations to Dr. Adam Brady for completing his PhD! Adam will take a postdoc position at NIH. Good Luck, Adam!
- April 2013: Welcome new postdoc Xiaolai Zhou, and visiting scientist Lirong Sun to the Lab!
- Dec. 2012: Fenghua is awarded research grant from MDA foundation to study TDP-43 aggregation.
- Oct. 2012: Our paper titled “The Frontotemporal Lobe degeneration risk factor, TMEM106B, regulates lysosomal morphology and function” is accepted for publication in Human Molecular Genetics.
- Sept. 2011: Fenghua is awarded AFTD 2011 Pilot Grant (http://www.theaftd.org/wp-content/uploads/2011/09/2011-Pilot-Grant-Release.pdf).
- Aug. 2011: Fenghua is granted New Investigator Award from the Alzheimer’s Association.
- June 2011: Our paper titled “C-terminus of Progranulin interacts with the beta-propeller region of Sortilin to regulate Progranulin trafficking” is published in PLoS One.
- Nov. 2010: Our paper titled “Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1” is accepted by Journal of Neurochemistry on Nov. 1st, 2010. The online version is out on Nov. 9th. Good job, Adam!
- Sept. 2010: Our joint publication with Dr. Strittmatter’s group on regulation of progranulin trafficking by sortilin is accepted by Neuron on September 7th, 2010. It will appear on the Nov. 18th issue of Neuron.
- Aug. 2010: Adam passed his A-exam on August 23rd, 2010. Congratulations, Adam!
- June 2010: Fenghua is awarded “The Rosalinde and Arthur Gilbert Foundation/AFAR New Investigator Awards in Alzheimer’s Disease”.